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Article

Zic2 is required for enteric nervous system development and neurite outgrowth: a mouse model of enteric hyperplasia and dysplasia.

Neurogastroenterology and motility - 1 Jun 2013

Zhang Y, Niswander L

Abstract excerpt

From a forward genetic screen in mice we isolated a novel Zic2 allele with abnormal aggregation of meconium in the gastrointestinal tract. Zic2(m1Nisw) mutant embryos show an increase in the number of enteric neurons in vivo and disorganization of the neurite network. Explant culture of Zic2(m1Nisw) gastrointestinal tract show extensive neurite outgrowth, suggesting that Zic2 is a negative regulator of nerve...

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Identifiers

PMID: 23413832
DOI: 10.1111/nmo.12101
PMCID: PMC3862053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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