Article
Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome.
PLoS genetics - 1 Jan 2013
Christmann Martin, Schmaler Tilo, Gordon Colin, Huang Xiaohua, Bayram Ozgür, Schinke Josua, Stumpf Sina, Dubiel Wolfgang, Braus Gerhard H
Abstract excerpt
Deneddylases remove the ubiquitin-like protein Nedd8 from modified proteins. An increased deneddylase activity has been associated with various human cancers. In contrast, we show here that a mutant strain of the model fungus Aspergillus nidulans deficient in two deneddylases is viable but can only grow as a filament and is highly impaired for multicellular development. The DEN1/DenA and the COP9 signalosome...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.