Article
Complex inheritance of melanoma and pigmentation of coat and skin in Grey horses.
PLoS genetics - 1 Jan 2013
Curik Ino, Druml Thomas, Seltenhammer Monika, Sundström Elisabeth, Pielberg Gerli Rosengren, Andersson Leif, Sölkner Johann
Abstract excerpt
The dominant phenotype of greying with age in horses, caused by a 4.6-kb duplication in intron 6 of STX17, is associated with a high incidence of melanoma and vitiligo-like skin depigmentation. However, the progressive greying and the incidence of melanoma, vitiligo-like depigmentation, and amount of speckling in these horses do not follow a simple inheritance pattern. To understand their inheritance, we analysed...
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