Article
Copy number expansion of the STX17 duplication in melanoma tissue from Grey horses.
BMC genomics - 2 Aug 2012
Sundström Elisabeth, Imsland Freyja, Mikko Sofia, Wade Claire, Sigurdsson Snaevar, Pielberg Gerli Rosengren, Golovko Anna, Curik Ino, Seltenhammer Monika H, Sölkner Johann, Lindblad-Toh Kerstin, Andersson Leif
Abstract excerpt
BACKGROUND: Greying with age in horses is an autosomal dominant trait, associated with loss of hair pigmentation, melanoma and vitiligo-like depigmentation. We recently identified a 4.6 kb duplication in STX17 to be associated with the phenotype. The aims of this study were to investigate if the duplication in Grey horses shows copy number variation and to exclude that any other polymorphism is uniquely...
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