Article
Comparing methods for performing trans-ethnic meta-analysis of genome-wide association studies.
Human molecular genetics - 1 Jun 2013
Wang Xu, Chua Hui-Xiang, Chen Peng, Ong Rick Twee-Hee, Sim Xueling, Zhang Weihua, Takeuchi Fumihiko, Liu Xuanyao, Khor Chiea-Chuen, Tay Wan-Ting, Cheng Ching-Yu, Suo Chen, Liu Jianjun, Aung Tin, Chia Kee-Seng, Kooner Jaspal S, Chambers John C, Wong Tien-Yin, Tai E-Shyong, Kato Norihiro, Teo Yik-Ying
Abstract excerpt
Genome-wide association studies (GWASs) have discovered thousands of variants that are associated with human health and disease. Whilst early GWASs have primarily focused on genetically homogeneous populations of European, East Asian and South Asian ancestries, the next-generation genome-wide surveys are starting to pool studies from ethnically diverse populations within a single meta-analysis. However, classical...
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