Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic screening: the future of antibody discovery.

Drug discovery today - 1 Jan 2016

Gonzalez-Munoz Andrea L, Minter Ralph R, Rust Steven J

Abstract excerpt

Most antibody therapeutics have been isolated from high throughput target-based screening. However, as the number of validated targets diminishes and the target space becomes increasingly competitive, alternative strategies, such as phenotypic screening, are gaining momentum. Here, we review successful phenotypic screens, including those used to isolate antibodies against cancer and infectious agents. We also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to Drug Discovery
Share to Mass Screening

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neoplasms

Share to Phenotype

Source

Identifiers

PMID: 26440132
DOI: 10.1016/j.drudis.2015.09.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic screening: the future of antibody discovery.PMID 26440132Read ↗

Advancements in mammalian display technology for therapeutic antibody development and beyond: current landscape, challenges, and future prospectsSemantic proximity Read ↗

Therapeutic antibody engineering by high efficiency cell screeningSemantic proximity Read ↗

Application of phage display to high throughput antibody generation and characterizationSemantic proximity Read ↗

Sequencing the functional antibody repertoire—diagnostic and therapeutic discoverySemantic proximity Read ↗

Retrocyte Display® technology: generation and screening of a high diversity cellular antibody library.Semantic proximity Read ↗

Discovery of diverse and functional antibodies from large human repertoire antibody librariesSemantic proximity Read ↗

Phenotypic Lentivirus Screens to Identify Antiviral Single Domain Antibodies.Semantic proximity Read ↗

The role of phage display in therapeutic antibody discoverySemantic proximity Read ↗

Design of synthetic antibody librariesSemantic proximity Read ↗

Development of a novel mammalian cell surface antibody display platformSemantic proximity Read ↗

Antibody display technologies: selecting the cream of the cropSemantic proximity Read ↗

Scalable High Throughput Selection From Phage-displayed Synthetic Antibody LibrariesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.