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Article

CYP3A4 genetic status may be associated with increased vulnerability to the inhibitory effect of calcium-channel blockers on clopidogrel.

Circulation journal : official journal of the Japanese Circulation Society - 1 Jan 2013

Park Jin Joo, Park Kyung Woo, Kang Jeehoon, Jeon Ki-Hyun, Kang Si-Hyuck, Ahn Hyo Suk, Han Jung-Kyu, Koh Jin-Sin, Lee Sang Eun, Yang Han-Mo, Lee Hae-Young, Kang Hyun-Jae, Koo Bon-Kwon, Oh Byung-Hee, Park Young-Bae, Kim Hyo-Soo

Abstract excerpt

BACKGROUND: Calcium-channel blockers (CCBs) inhibit the CYP3A4 enzyme, which is involved in clopidogrel activation. Studies have shown conflicting results regarding the effect of concomitant CCB administration on clopidogrel response. We investigated the relationship between CYP3A4 genotype and the inhibitory effect of CCBs on clopidogrel response. METHODS AND RESULTS: Clopidogrel on-treatment platelet reactivity...

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Source

Identifiers

PMID: 23400261
DOI: 10.1253/circj.cj-12-0682

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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