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Article

Genetic variants in AR and SHBG and resistance to hormonal castration in prostate cancer.

Medical oncology (Northwood, London, England) - 1 Mar 2013

Monteiro Cátia, Sousa Marta Velho, Ribeiro Ricardo, Maurício Joaquina, Fraga Avelino, Medeiros Rui

Abstract excerpt

Castration resistance is a life-threatening event that may develop in prostate cancer patients with advanced disease following hormonal castration therapy (HCT). Current understanding of the molecular mechanisms behind resistance to hormonal castration suggests a role for androgen receptor signaling and bioavailability of androgens. We evaluated whether common functional polymorphisms in AR and SHBG genes...

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Share to Adenocarcinoma
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Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms, Hormone-Dependent

Share to Polymorphism, Single Nucleotide

Share to Prostatic Neoplasms

Share to Receptors, Androgen

Share to Sex Hormone-Binding Globulin

Source

Identifiers

PMID: 23397084
DOI: 10.1007/s12032-013-0490-2

Genes

SHBG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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