Article
The effects of gene polymorphisms in interleukin-4 and interleukin-6 on the susceptibility of rheumatoid arthritis in a Chinese population.
BioMed research international - 1 Jan 2014
Li Xiang, Chai Wei, Ni Ming, Xu Meng, Lian Zijian, Shi Lewis, Bai Yang, Wang Yan
Abstract excerpt
BACKGROUND: Interleukin-4 (IL-4) and interleukin-6 (IL-6) have been reported to associate with pathogenesis of rheumatoid arthritis (RA); however, the role of IL-4 and IL-6 genetic polymorphisms in RA remains unknown. METHOD: A total of 752 unrelated Chinese patients with RA and 798 healthy Chinese volunteers with no family histories of any autoimmune diseases were recruited. The promoter IL-4-590 C/T and...
Topics
- Alleles
- Arthritis, Rheumatoid
- Asian People
- Case-Control Studies
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Interleukin-4
- Interleukin-6
- Male
- Middle Aged
- Polymorphism, Single Nucleotide