Article
Functional studies of the Ciona intestinalis myogenic regulatory factor reveal conserved features of chordate myogenesis.
Developmental biology - 15 Apr 2013
Izzi Stephanie A, Colantuono Bonnie J, Sullivan Kelly, Khare Parul, Meedel Thomas H
Abstract excerpt
Ci-MRF is the sole myogenic regulatory factor (MRF) of the ascidian Ciona intestinalis, an invertebrate chordate. In order to investigate its properties we developed a simple in vivo assay based on misexpressing Ci-MRF in the notochord of Ciona embryos. We used this assay to examine the roles of three structural motifs that are conserved among MRFs: an alanine-threonine (Ala-Thr) dipeptide of the basic domain...
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