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Article

Vac14 protein multimerization is a prerequisite step for Fab1 protein complex assembly and function.

The Journal of biological chemistry - 29 Mar 2013

Alghamdi Tamadher A, Ho Cheuk Y, Mrakovic Amra, Taylor Danielle, Mao Daniel, Botelho Roberto J

Abstract excerpt

Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) helps control various endolysosome functions including organelle morphology, membrane recycling, and ion transport. Further highlighting its importance, PtdIns(3,5)P2 misregulation leads to the development of neurodegenerative diseases like Charcot-Marie-Tooth disease. The Fab1/PIKfyve lipid kinase phosphorylates PtdIns(3)P into PtdIns(3,5)P2 whereas the...

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Identifiers

PMID: 23389034
DOI: 10.1074/jbc.M113.453712
PMCID: PMC3611006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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