Article
Calmodulin mutations associated with recurrent cardiac arrest in infants.
Circulation - 5 Mar 2013
Crotti Lia, Johnson Christopher N, Graf Elisabeth, De Ferrari Gaetano M, Cuneo Bettina F, Ovadia Marc, Papagiannis John, Feldkamp Michael D, Rathi Subodh G, Kunic Jennifer D, Pedrazzini Matteo, Wieland Thomas, Lichtner Peter, Beckmann Britt-Maria, Clark Travis, Shaffer Christian, Benson D Woodrow, Kääb Stefan, Meitinger Thomas, Strom Tim M, Chazin Walter J, Schwartz Peter J, George Alfred L
Abstract excerpt
BACKGROUND: Life-threatening disorders of heart rhythm may arise during infancy and can result in the sudden and tragic death of a child. We performed exome sequencing on 2 unrelated infants presenting with recurrent cardiac arrest to discover a genetic cause. METHODS AND RESULTS: We ascertained 2 unrelated infants (probands) with recurrent cardiac arrest and dramatically prolonged QTc interval who were both born...
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