Article
Poor reproducibility of allergic rhinitis SNP associations.
PloS one - 1 Jan 2013
Nilsson Daniel, Andiappan Anand Kumar, Halldén Christer, Tim Chew Fook, Säll Torbjörn, Wang De Yun, Cardell Lars-Olaf
Abstract excerpt
Replication of reported associations is crucial to the investigation of complex disease. More than 100 SNPs have previously been reported as associated with allergic rhinitis (AR), but few of these have been replicated successfully. To investigate the general reproducibility of reported AR-associations in candidate gene studies, one Swedish (352 AR-cases, 709 controls) and one Singapore Chinese population (948...
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