Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells.

doi:10.1073/pnas.1217039110

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Article

Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells.

Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2013

Hiramoto Takafumi, Ebihara Yasuhiro, Mizoguchi Yoko, Nakamura Kazuhiro, Yamaguchi Kiyoshi, Ueno Kazuko, Nariai Naoki, Mochizuki Shinji, Yamamoto Shohei, Nagasaki Masao, Furukawa Yoichi, Tani Kenzaburo, Nakauchi Hiromitsu, Kobayashi Masao, Tsuji Kohichiro

Abstract excerpt

The derivation of induced pluripotent stem (iPS) cells from individuals of genetic disorders offers new opportunities for basic research into these diseases and the development of therapeutic compounds. Severe congenital neutropenia (SCN) is a serious disorder characterized by severe neutropenia at birth. SCN is associated with heterozygous mutations in the neutrophil elastase [elastase, neutrophil-expressed...

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Identifiers

PMID: 23382209
DOI: 10.1073/pnas.1217039110
PMCID: PMC3581925

Genes

ELANE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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