Phenotype-environment mismatch due to epigenetic inheritance? Programming the offspring's epigenome and the consequences of migration.

Abstract excerpt

OBJECTIVE: It has been suggested that epigenetic inheritance is an important factor influencing mortality. We use data about the historical population of Québec (years 1670-1740) to study whether parents modify their offspring's phenotype epigenetically prior to conception in response to predicted/perceived mortality. If so, children growing up in the predicted environment enjoy a phenotype-environment-match that...

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