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Article

Multigenerational epigenetic effects of nicotine on lung function

4 Feb 2013

Abstract excerpt

A recent preclinical study has shown that not only maternal smoking but also grandmaternal smoking is associated with elevated pediatric asthma risk. Using a well-established rat model of in utero nicotine exposure, Rehan et al. have now demonstrated multigenerational effects of nicotine that could explain this 'grandmother effect'. F1 offspring of nicotine-treated pregnant rats exhibited asthma-like changes to...

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PMID: 23379695
DOI: 10.1186/1741-7015-11-27

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