Article
Testing for association in case-control genome-wide association studies with shared controls.
Statistical methods in medical research - 1 Apr 2016
Chen Zhongxue, Huang Hanwen, Ng Hon Keung Tony
Abstract excerpt
The statistical analysis of genome-wide association studies (GWASs) with multiple diseases and shared controls (SCs) is discussed. The usual method for analyzing data from these studies is to compare each individual disease with either the SCs or the pooled controls which include other diseases. We observed that applying individual association tests can be problematic because these tests may suffer from power...
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