Article
The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis.
PloS one - 1 Jan 2013
Samson Thomas, van Buul Jaap D, Kroon Jeffrey, Welch Christopher, Bakker Erik N, Matlung Hanke L, van den Berg Timo K, Sharek Lisa, Doerschuk Claire, Hahn Klaus, Burridge Keith
Abstract excerpt
The passage of leukocytes across the endothelium and into arterial walls is a critical step in the development of atherosclerosis. Previously, we showed in vitro that the RhoG guanine nucleotide exchange factor SGEF (Arhgef26) contributes to the formation of ICAM-1-induced endothelial docking structures that facilitate leukocyte transendothelial migration. To further explore the in vivo role of this protein...
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