Article
Common variation neighbouring micro-RNA 22 is associated with increased left ventricular mass.
PloS one - 1 Jan 2013
Harper Andrew R, Mayosi Bongani M, Rodriguez Antony, Rahman Thahira, Hall Darroch, Mamasoula Chrysovalanto, Avery Peter J, Keavney Bernard D
Abstract excerpt
AIMS: Previous genome-wide linkage analysis has suggested that chromosomal region 17p13.3 may harbour genes influencing left ventricular mass (LVM) in man. To date, the genetic factors accounting for LVM variability remain largely unknown but a non-coding RNA gene within this region, micro-RNA 22 (miR-22), has been implicated in cardiac hypertrophy and heart failure in animal models. We thus investigated the...
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