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Article

Rare Copy Number Variants Identified Suggest the Regulating Pathways in Hypertension-Related Left Ventricular Hypertrophy.

PloS one - 1 Jan 2016

Boon-Peng Hoh, Mat Jusoh Julia Ashazila, Marshall Christian R, Majid Fadhlina, Danuri Norlaila, Basir Fashieha, Thiruvahindrapuram Bhooma, Scherer Stephen W, Yusoff Khalid

Abstract excerpt

Left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular morbidity and mortality, and a powerful predictor of adverse cardiovascular outcomes in the hypertensive patients. It has complex multifactorial and polygenic basis for its pathogenesis. We hypothesized that rare copy number variants (CNVs) contribute to the LVH pathogenesis in hypertensive patients. Copy number variants (CNV)...

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PMID: 26930585
DOI: 10.1371/journal.pone.0148755
PMCID: PMC4773219

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