(S)-Selective MenD variants from Escherichia coli provide access to new functionalized chiral α-hydroxy ketones.

Abstract excerpt

We report the first rationally designed (S)-selective MenD from E. coli for the synthesis of functionalized α-hydroxy ketones. By mutation of two amino acids in the active site stereoselectivity of the (R)-selective EcMenD (ee > 93%) was inverted giving access to (S)-5-hydroxy-4-oxo-5-phenylpenta...

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