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Article

New bioorganic reagents: evolved cyclohexanone monooxygenase--why is it more selective?

The Journal of organic chemistry - 27 Oct 2006

Kayser Margaret M, Clouthier Christopher M

Abstract excerpt

Four mutants of the cyclohexanone monooxygenase (CHMO) evolved as catalysts for Baeyer-Villiger oxidation of 4-hydroxycyclohexanone were investigated as catalysts for a variety of 4-substituted and 4,4-disubstituted cyclohexanones. Several excellent catalytic matches (mutant/substrate) were identified. The most important, however, is the finding that, in a number of cases, a mutant with a single exchange,...

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PMID: 17064015
DOI: 10.1021/jo061349t

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