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Article

Involvement of mtDNA damage elicited by oxidative stress in the arsenical skin cancers.

The Journal of investigative dermatology - 1 Jul 2013

Lee Chih-Hung, Wu Shi-Bei, Hong Chien-Hui, Chen Gwo-Shin, Wei Yau-Huei, Yu Hsin-Su

Abstract excerpt

Arsenic causes several human cancers. Arsenic-induced Bowen's disease (As-BD), the most common arsenical cancer, is characterized by increased proliferation, dysplasia, and individual cell apoptosis, all of which involve mitochondria. We reported that arsenic causes aberrant keratinocyte proliferation through mtTFA-mediated mitochondrial biogenesis in As-BD. Increasing mitochondrial biogenesis causes cells to...

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Identifiers

PMID: 23370535
DOI: 10.1038/jid.2013.55

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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