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Article

Polymorphisms of muscle genes are associated with bone mass and incident osteoporotic fractures in Caucasians.

Calcified tissue international - 1 May 2013

Harsløf T, Frost M, Nielsen T L, Husted L B, Nyegaard M, Brixen K, Børglum A D, Mosekilde L, Andersen M, Rejnmark L, Langdahl B L

Abstract excerpt

The interaction between muscle and bone is complex. The aim of this study was to investigate if variations in the muscle genes myostatin (MSTN), its receptor (ACVR2B), myogenin (MYOG), and myoD1 (MYOD1) were associated with fracture risk, bone mineral density (BMD), bone mineral content (BMC), and lean body mass. We analyzed two independent cohorts: the Danish Osteoporosis Prevention Study (DOPS), comprising...

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Identifiers

PMID: 23370486
DOI: 10.1007/s00223-013-9702-1

Genes

MSTN
MYOD1
MYOG

Provenance

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