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Article

Differential viral RNA methylation contributes to pathogen blocking in Wolbachia-colonized arthropods

16 Mar 2022

Abstract excerpt

Arthropod endosymbiont Wolbachia pipientis is part of a global biocontrol strategy to reduce the replication of mosquito-borne RNA viruses such as alphaviruses. We previously demonstrated the importance of a host cytosine methyltransferase, DNMT2, in Drosophila and viral RNA as a cellular target during pathogen-blocking. Here we report a role for DNMT2 in Wolbachia-induced alphavirus inhibition in Aedes species....

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PMID: 35294495
DOI: 10.1371/journal.ppat.1010393

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