Article
Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence.
Nature - 31 Jan 2013
Tabach Yuval, Billi Allison C, Hayes Gabriel D, Newman Martin A, Zuk Or, Gabel Harrison, Kamath Ravi, Yacoby Keren, Chapman Brad, Garcia Susana M, Borowsky Mark, Kim John K, Ruvkun Gary
Abstract excerpt
Genetic and biochemical analyses of RNA interference (RNAi) and microRNA (miRNA) pathways have revealed proteins such as Argonaute and Dicer as essential cofactors that process and present small RNAs to their targets. Well-validated small RNA pathway cofactors such as these show distinctive patterns of conservation or divergence in particular animal, plant, fungal and protist species. We compared 86 divergent...
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Eukaryota
- Genetic Variation
- Genome
- MicroRNAs
- Phylogeny
- Proteome
- RNA Splicing
- RNA, Small Interfering