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Article

Apoe, Mbl2, and Psp plasma protein levels correlate with diabetic phenotype in NZO mice--an optimized rapid workflow for SRM-based quantification.

Journal of proteome research - 1 Mar 2013

von Toerne Christine, Kahle Melanie, Schäfer Alexander, Ispiryan Ruben, Blindert Marcel, Hrabe De Angelis Martin, Neschen Susanne, Ueffing Marius, Hauck Stefanie M

Abstract excerpt

Male New Zealand Obese (NZO) mice progress through pathophysiological stages similar to humans developing obesity-associated type 2 diabetes (T2D). The current challenge is to establish quantitative proteomics from small plasma sample amounts. We established an analytical workflow that facilitates a reproducible depletion of high-abundance proteins, has high throughput applicability, and allows absolute...

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Share to Chromatography, High Pressure Liquid
Share to Diabetes Mellitus, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme-Linked Immunosorbent Assay

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Source

Identifiers

PMID: 23350727
DOI: 10.1021/pr3009836

Genes

SRM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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