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Partial Functional Complementation between Human and Mouse Cytomegalovirus Chemokine Receptor Homologues

14 Apr 2011

Abstract excerpt

The human cytomegalovirus (CMV) proteins US28 and UL33 are homologous to chemokine receptors (CKRs). Knockout of the mouse CMV M33 protein (UL33 homologue) results in substantial attenuation of salivary gland infection/replication and reduced efficiency of reactivation from tissue explants. M33-mediated G protein-coupled signaling is critical for the salivary gland phenotype. In this report, we demonstrate that...

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PMID: 21490099
DOI: 10.1128/jvi.02113-10

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