Article
Bioinformatic analysis of benzo-α-pyrene-induced damage to the human placental insulin-like growth factor-1 gene.
Reproductive sciences (Thousand Oaks, Calif.) - 1 Aug 2013
Fadiel A, Epperson B, Shaw M I, Hamza A, Petito J, Naftolin F
Abstract excerpt
INTRODUCTION: Intrauterine growth restriction (IUGR) has been associated with exposure to polyaromatic hydrocarbons (PAHs) which are released in the combustion of oil, fuel, gas, garbage, and tobacco. Pregnant women exposed to PAHs are at risk of the effects of these environmental toxins; for example, benzo-α-pyrene (BαP) is able to enter the blood stream and could contribute to IUGR or other developmental...
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