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Epidermal growth factor receptor in placental health and disease: pathways, dysfunction, and chemical disruption

22 Feb 2025

Abstract excerpt

Formation of the placenta during gestation is required to support fetal growth and development. Derived from the placenta, trophoblast cells express nuclear and membrane-bound receptors. Among these receptors is the epidermal growth factor receptor (EGFR) which plays a key role in placental development. Activation of EGFR-mediated signaling in trophoblast cells regulates critical processes, such as proliferation,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39985453
DOI: 10.1093/toxsci/kfaf024

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