Article
Responsiveness to a physiological regimen of GnRH therapy and relation to genotype in women with isolated hypogonadotropic hypogonadism.
The Journal of clinical endocrinology and metabolism - 1 Feb 2013
Abel Brent S, Shaw Natalie D, Brown Jenifer M, Adams Judith M, Alati Teresa, Martin Kathryn A, Pitteloud Nelly, Seminara Stephanie B, Plummer Lacey, Pignatelli Duarte, Crowley William F, Welt Corrine K, Hall Janet E
Abstract excerpt
CONTEXT: Isolated hypogonadotropic hypogonadism (IHH) is caused by defective GnRH secretion or action resulting in absent or incomplete pubertal development and infertility. Most women with IHH ovulate with physiological GnRH replacement, implicating GnRH deficiency as the etiology. However, a subset does not respond normally, suggesting the presence of defects at the pituitary or ovary. OBJECTIVES: The objective...
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