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Article

A genetic basis for functional hypothalamic amenorrhea.

The New England journal of medicine - 20 Jan 2011

Caronia Lisa M, Martin Cecilia, Welt Corrine K, Sykiotis Gerasimos P, Quinton Richard, Thambundit Apisadaporn, Avbelj Magdalena, Dhruvakumar Sadhana, Plummer Lacey, Hughes Virginia A, Seminara Stephanie B, Boepple Paul A, Sidis Yisrael, Crowley William F, Martin Kathryn A, Hall Janet E, Pitteloud Nelly

Abstract excerpt

BACKGROUND: Functional hypothalamic amenorrhea is a reversible form of gonadotropin-releasing hormone (GnRH) deficiency commonly triggered by stressors such as excessive exercise, nutritional deficits, or psychological distress. Women vary in their susceptibility to inhibition of the reproductive axis by such stressors, but it is unknown whether this variability reflects a genetic predisposition to hypothalamic...

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Share to Amenorrhea
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Luteinizing Hormone

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Share to Receptor, Fibroblast Growth Factor, Type 1

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Source

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Identifiers

PMID: 21247312
DOI: 10.1056/NEJMoa0911064
PMCID: PMC3045842

Genes

FGFR1
PROKR2
GNRHR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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