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Article

Mutation profiles and clinical characteristics of Chinese males with isolated hypogonadotropic hypogonadism.

Fertility and sterility - 1 Aug 2018

Zhou Chengming, Niu Yonghua, Xu Hao, Li Zongzhe, Wang Tao, Yang Weimin, Wang Shaogang, Wang Dao Wen, Liu Jihong

Abstract excerpt

OBJECTIVE: To investigate the mutation profiles and clinical characteristics of Chinese males with isolated hypogonadotropic hypogonadism (IHH) and discover new pathogenic genes that cause IHH. DESIGN: A gene panel, including 31 known IHH genes and 52 candidate genes, was used to perform semiconductor next-generation sequencing. SETTING: University hospital. PATIENTS: One hundred thirty-eight sporadic male IHH...

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Source

Identifiers

PMID: 30098700
DOI: 10.1016/j.fertnstert.2018.04.010

Genes

IHH
CHD7
EGFR
ERBB4
FGFR1
IGF1
PAX6
PROKR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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