Article
Congenital idiopathic hypogonadotropic hypogonadism: evidence of defects in the hypothalamus, pituitary, and testes.
The Journal of clinical endocrinology and metabolism - 1 Jun 2010
Sykiotis Gerasimos P, Hoang Xuan-Huong, Avbelj Magdalena, Hayes Frances J, Thambundit Apisadaporn, Dwyer Andrew, Au Margaret, Plummer Lacey, Crowley William F, Pitteloud Nelly
Abstract excerpt
CONTEXT: Idiopathic hypogonadotropic hypogonadism (IHH) with normal smell (normosmic IHH) or anosmia (Kallmann syndrome) is associated with defects in the production or action of GnRH. Accordingly, most IHH patients respond to physiological pulsatile GnRH replacement by normalizing serum LH, FSH, and testosterone (T) levels and achieving gametogenesis; some patients, however, show atypical responses....
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