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Article

IGF1 Receptor Signaling Regulates Adaptive Radioprotection in Glioma Stem Cells

18 Jan 2013

Abstract excerpt

Cancer stem cells (CSCs) play an important role in disease recurrence after radiation treatment as a result of intrinsic properties such as high DNA repair capability and antioxidative capacity. It is unclear, however, how CSCs further adapt to escape the toxicity of the repeated irradiation regimens used in clinical practice. Here, we have exposed a population of murine glioma stem cells (GSCs) to fractionated...

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PMID: 23335250
DOI: 10.1002/stem.1328

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