Article
Polymorphisms in microRNA target sites influence susceptibility to schizophrenia by altering the binding of miRNAs to their targets.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Oct 2013
Gong Yunguo, Wu Chao N, Xu Jiawei, Feng Guoyin, Xing Q H, Fu W, Li Chong, He L, Zhao X Z
Abstract excerpt
Single nucleotide polymorphisms (SNPs) in 3' untranslated regions (3' UTRs) of genes may affect miRNA binding to messenger RNA and contribute to the risk of disease. Whether the SNPs that modify miRNA binding in the 3' UTR are involved in schizophrenia-related genes remains unclear. We selected 803 SNPs from the 3' UTRs of 425 candidate genes for schizophrenia. The potential target SNPs were recognized by Gibbs...
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