Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vitro mechanism for downregulation of <scp>ER</scp> ‐α expression by epigallocatechin gallate in <scp>ER</scp> +/ <scp>PR</scp> + human breast cancer cells

16 Jan 2013

Abstract excerpt

SCOPE: Exposure of the breast to estrogens and other sex hormones is an important cancer risk factor and estrogen receptor downregulators are attracting significant clinical interest. Epigallocatechin gallate (EGCG), a polyphenolic compound found in green tea, has gained considerable attention for its antitumor properties. Here we aimed to investigate the molecular mechanisms through which EGCG regulates ER-α...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antioxidant Activity and Oxidative Stress
Share to Estrogen and related hormone effects
Share to Tea Polyphenols and Effects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23322423
DOI: 10.1002/mnfr.201200560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vitro mechanism for downregulation of <scp>ER</scp> ‐α expression by epigallocatechin gallate in <scp>ER</scp> +/ <scp>PR</scp> + human breast cancer cellsPMID 23322423Read ↗

Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cellsSemantic proximity Read ↗

Molecular Targets of Epigallocatechin—Gallate (EGCG): A Special Focus on Signal Transduction and CancerSemantic proximity Read ↗

Suppression of Wnt Signaling by the Green Tea Compound (–)-Epigallocatechin 3-Gallate (EGCG) in Invasive Breast Cancer CellsSemantic proximity Read ↗

ER-α36 mediates cisplatin resistance in breast cancer cells through EGFR/HER-2/ERK signaling pathway.Semantic proximity Read ↗

Epigenetic down regulation of G protein-coupled estrogen receptor (GPER) functions as a tumor suppressor in colorectal cancerSemantic proximity Read ↗

Reduction in promotor methylation utilizing EGCG (epigallocatechin-3-gallate) restores RXRα expression in human colon cancer cellsSemantic proximity Read ↗

Targeting Receptor Tyrosine Kinases for Chemoprevention by Green Tea Catechin, EGCGSemantic proximity Read ↗

Cell growth inhibition and gene expression regulation by (-)-epigallocatechin-3-gallate in human cervical cancer cellsSemantic proximity Read ↗

Green tea polyphenol and curcumin inversely regulate human involucrin promoter activity via opposing effects on CCAAT/enhancer-binding protein function.Semantic proximity Read ↗

Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cellsSemantic proximity Read ↗

Expression of NSAID-activated gene-1 by EGCG in head and neck cancer: involvement of ATM-dependent p53 expressionSemantic proximity Read ↗

Gαo potentiates estrogen receptor α activity via the ERK signaling pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.