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Article

Gαo potentiates estrogen receptor α activity via the ERK signaling pathway.

The Journal of endocrinology - 1 Jul 2012

Bratton Melyssa R, Antoon James W, Duong Bich N, Frigo Daniel E, Tilghman Syreeta, Collins-Burow Bridgette M, Elliott Steven, Tang Yan, Melnik Lilia I, Lai Ling, Alam Jawed, Beckman Barbara S, Hill Steven M, Rowan Brian G, McLachlan John A, Burow Matthew E

Abstract excerpt

The estrogen receptor α (ERα) is a transcription factor that mediates the biological effects of 17β-estradiol (E(2)). ERα transcriptional activity is also regulated by cytoplasmic signaling cascades. Here, several Gα protein subunits were tested for their ability to regulate ERα activity. Reporte...

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Identifiers

PMID: 22562654
DOI: 10.1530/JOE-12-0097
PMCID: PMC3614348

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22562654-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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