Suppression of Wnt Signaling by the Green Tea Compound (–)-Epigallocatechin 3-Gallate (EGCG) in Invasive Breast Cancer Cells

Abstract excerpt

Genetic and biochemical de-regulation of Wnt signaling is correlated with breast and other cancers. Our goal was to identify compounds that block Wnt signaling as a first step toward investigating new strategies for suppression of invasive and other breast cancers. In a limited phytonutrient screen, EGCG ((-)-epigallocatechin 3-gallate), the major phytochemical in green tea, emerged as an intriguing candidate....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Phytoestrogen effects and research
• Share to Tea Polyphenols and Effects
• Share to Wnt/β-catenin signaling in development and cancer