Article
GATA4 and DcR1 methylation in glioblastomas.
Diagnostic pathology - 15 Jan 2013
Vaitkienė Paulina, Skiriutė Daina, Skauminas Kęstutis, Tamašauskas Arimantas
Abstract excerpt
BACKGROUND: Epigenetic silencing of tumor suppressor genes plays important role in gliomagenesis. Recently, GATA4 and DcR1 were suggested to be a tumor suppressor genes involved in tumorigenesis in various types of human cancers. However, up to now the methylation frequency of GATA4 and DcR1 genes has not been determined in glioblastoma. In this study, we investigated methylation of GATA4 and DcR1 promoters and...
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