Article
Interactions and predicted host membrane topology of the enteropathogenic Escherichia coli translocator protein EspB.
Journal of bacteriology - 1 Jun 2011
Luo Wensheng, Donnenberg Michael S
Abstract excerpt
Type 3 secretion systems (T3SSs) are critical for the virulence of numerous deadly Gram-negative pathogens. T3SS translocator proteins are required for effector proteins to traverse the host cell membrane and perturb cell function. Translocator proteins include two hydrophobic proteins, represented in enteropathogenic Escherichia coli (EPEC) by EspB and EspD, which are thought to interact and form a pore in the...
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