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Article

Predicting functional effect of human missense mutations using PolyPhen-2.

Current protocols in human genetics - 1 Jan 2013

Adzhubei Ivan, Jordan Daniel M, Sunyaev Shamil R

Abstract excerpt

PolyPhen-2 (Polymorphism Phenotyping v2), available as software and via a Web server, predicts the possible impact of amino acid substitutions on the stability and function of human proteins using structural and comparative evolutionary considerations. It performs functional annotation of single-nucleotide polymorphisms (SNPs), maps coding SNPs to gene transcripts, extracts protein sequence annotations and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 23315928
DOI: 10.1002/0471142905.hg0720s76
PMCID: PMC4480630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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