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Effect of Bone Morphogenetic Protein-4 on the Expression of Sox2, Oct-4, and c-Myc in Human Periodontal Ligament Cells During Long-Term Culture

11 Jan 2013

Abstract excerpt

Recent studies demonstrated that the endogenous expression level of Sox2, Oct-4, and c-Myc is correlated with the pluripotency and successful induction of induced pluripotent stem cells. Periodontal ligament cells (PDLCs) have a multilineage differentiation capability and ability to maintain the undifferentiated stage, which makes PDLCs a suitable cell source for tissue repair and regeneration. To elucidate the...

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PMID: 23311397
DOI: 10.1089/scd.2012.0548

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