Article
Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal α-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition.
PloS one - 1 Jan 2012
Morgan Rhodri M L, Hernández-Ramírez Laura C, Trivellin Giampaolo, Zhou Lihong, Roe S Mark, Korbonits Márta, Prodromou Chrisostomos
Abstract excerpt
Mutations of the aryl hydrocarbon receptor interacting protein (AIP) have been associated with familial isolated pituitary adenomas predisposing to young-onset acromegaly and gigantism. The precise tumorigenic mechanism is not well understood as AIP interacts with a large number of independent proteins as well as three chaperone systems, HSP90, HSP70 and TOMM20. We have determined the structure of the TPR domain...
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