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Tumor necrosis factor alpha -238G/A (rs 361525) gene polymorphism predicts progression to type-2 diabetes in an Eastern Indian population with prediabetes.

Diabetes research and clinical practice - 1 Mar 2013

Dutta Deep, Choudhuri Subhadip, Mondal Samim Ali, Maisnam Indira, Reza Abu Hena Hasanoor, Ghosh Sujoy, Chowdhury Subhankar, Bhattacharya Basudev, Mukhopadhyay Satinath

Abstract excerpt

Prediabetes (IPD; n=122) and normoglycemic individuals (n=100) underwent assessment of polymorphisms of TNFα (-238, -308) and IL6 (-174). After 27.25±5.64 months, 16 IPD had reverted to normoglycemia and 18 progressed to diabetes. TNFα -238AA/GA genotypes were significantly more common in IPD, ha...

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Identifiers

PMID: 23298660
DOI: 10.1016/j.diabres.2012.12.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23298660-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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