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Article

Zinc Finger Nuclease induced DNA double stranded breaks and rearrangements in MLL.

Mutation research - 1 Dec 2012

Do To Uyen, Ho Bay, Shih Shyh-Jen, Vaughan Andrew

Abstract excerpt

Radiation treatment or chemotherapy has been linked with a higher risk of secondary cancers such as therapy related Acute Myeloid Leukemia (tAML). Several of these cancers have been shown to be correlated to the introduction of double stranded breaks (DSB) and rearrangements within the Mixed Lineage Leukemia (MLL) gene. We used Zinc Finger Nucleases (ZFNs) to introduce precise cuts within MLL to examine how a...

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Share to DNA Breaks, Double-Stranded
Share to DNA Fragmentation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endodeoxyribonucleases

Share to Leukemia, Myeloid, Acute

Share to Mutagenesis, Insertional

Share to Myeloid-Lymphoid Leukemia Protein

Share to Translocation, Genetic

Source

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Identifiers

PMID: 23291497
DOI: 10.1016/j.mrfmmm.2012.12.006
PMCID: PMC3578303

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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