Article
Novel and recurrent mutations in the filaggrin gene in Chinese patients with ichthyosis vulgaris.
The British journal of dermatology - 1 Jul 2010
Zhang X, Liu S, Chen X, Zhou B, Liu D, Lei G, Xiao X, Liu H, Wang H
Abstract excerpt
BACKGROUND: Ichthyosis vulgaris (IV) is a common inherited skin disorder, and the filament aggregating protein (filaggrin) is a key protein involved in skin barrier function. Mutations in the filaggrin gene (FLG) have recently been identified as the cause of IV. However, there have been no reports of FLG mutations in mainland Chinese families with IV. OBJECTIVES: To identify FLG mutations in Chinese patients with...
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