Article
Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice.
Molecular neurodegeneration - 3 Jan 2013
Qiu Linghua, Qiao Tao, Beers Melissa, Tan Weijia, Wang Hongyan, Yang Bin, Xu Zuoshang
Abstract excerpt
BACKGROUND: A proline-to-serine substitution at position-56 (P56S) of vesicle-associated membrane protein-associated protein B (VAPB) causes a form of dominantly inherited motor neuron disease (MND), including typical and atypical amyotrophic lateral sclerosis (ALS) and a mild late-onset spinal muscular atrophy (SMA). VAPB is an integral endoplasmic reticulum (ER) protein and has been implicated in various...
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