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Article

Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology.

Neuroscience - 19 May 2010

Tudor E L, Galtrey C M, Perkinton M S, Lau K-F, De Vos K J, Mitchell J C, Ackerley S, Hortobágyi T, Vámos E, Leigh P N, Klasen C, McLoughlin D M, Shaw C E, Miller C C J

Abstract excerpt

Cytoplasmic ubiquitin-positive inclusions containing TAR-DNA-binding protein-43 (TDP-43) within motor neurons are the hallmark pathology of sporadic amyotrophic lateral sclerosis (ALS). TDP-43 is a nuclear protein and the mechanisms by which it becomes mislocalized and aggregated in ALS are not p...

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Source

Identifiers

PMID: 20188146
DOI: 10.1016/j.neuroscience.2010.02.035

Genes

VAPB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20188146-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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