Article
Association between the FOXP2 gene and autistic disorder in Chinese population.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 May 2004
Gong Xiaohong, Jia Meixiang, Ruan Yan, Shuang Mei, Liu Jing, Wu Suping, Guo Yanqing, Yang Jianzhong, Ling Yansu, Yang Xiaoling, Zhang Dai
Abstract excerpt
Several genomewide screens indicated that chromosome 7q was linked to autistic disorder. FOXP2, located on 7q31, is a putative transcription factor containing a polyglutamine tract and a forkhead DNA binding domain. It is one member of the forkhead family who are known to be key regulators of embryogenesis. A point mutation at a highly conserved residue within the forkhead domain co-segregated with affected...
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